Hyperammonemic encephalopathy: Time course of MRI diffusion changes

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Hyperammonemic encephalopathy: time course of MRI diffusion changes.

A 55-year-old man with cirrhosis presented with hyperammonemic encephalopathy, subsequently fatal (plasma ammonia level 410 M/L). Three-Tesla MRI initially showed restricted diffusion (figure 1A) in the cerebral cortex, suggesting poor prognosis,1 thalami, and striatum. Apparent diffusion coefficient pseudonormalized 8 days after admission (figure 1B), comparable to the evolution of hypoxic enc...

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The use of valproic acid (VPA) (also known as Depakote, Depakene, and others) frequently results in elevated plasma ammonia. In some people, hyperammonemia may be clinically significant, resulting in hyperammonemic encephalopathy, which may be severe. Valproic acid-induced hyperammonemic encephalopathy may occur in people with normal liver function, despite normal doses and serum levels of VPA....

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Valproate-Induced Hyperammonemic Encephalopathy

Valproate is the best choice drug for a variety of medical conditions. As with any other drug, it has adverse effects, and it is important to emphasize the possibility of those adverse effects to prevent complications. We present the case history of a 44-year-old male with valproate-induced hyperammonemic encephalopathy, despite having normal liver function tests. This case includes a detailed ...

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Encefalopatia hiperamonemica inducida por acido valproico.

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ژورنال

عنوان ژورنال: Neurology

سال: 2012

ISSN: 0028-3878,1526-632X

DOI: 10.1212/wnl.0b013e318247ccd1